
Recombinant measles vectors for highly immunogenic vaccines
The live recombinant MV vaccine induces long-lived immunity against measles after a single immunization. MV-based recombinant vaccine candidates for hepatitis B, HIV, West Nile virus, and SARS have been successfully constructed and tested in pre-clinical vaccine models. Potent humorally neutralizing antibodies and cellular immunity have been elicited by MV-based vector. The elicited immune responses were long-lived and comparable to the parental MV vaccine.
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