Crucell’s MAbstract® technology is a human antibody-based phage display system, which facilitates the discovery of novel drug targets and the identification of human monoclonal antibodies against those targets. A phage (or ‘bacteriophage’) is a virus that can infect and multiply in bacteria. In phage display technology, phages are genetically engineered to expresses the pathogen-binding part of a human antibody on their surfaces. In the MAbstract® technology, a library of phages exposing a wide variety of human antibodies fragments on their surfaces is brought into contact with disease-causing microorganisms (pathogens) or parts of pathogens in order to identify human antibodies that selectively bind to targets of interest.
MAbstract® technology is an efficient method for the discovery of human antibodies to be applied for the prevention, diagnosis and therapy of diseases.
MAbstract® technology has a number of potential advantages over other technologies currently used for generating antibodies.