Crucell is currently developing a monoclonal antibody product for post exposure treatment against rabies. Discovered using MAbstract^® technology and produced on PER.C6^® technology, the product is a combination of two human anti-rabies antibodies. For further information on this program please refer to our R&D section of the website or download the following documents.

• About Rabies (PDF)

01 Oct. 2008: Crucell Announces Positive Results of Phase II Clinical Study Rabies Monoclonal Antibody Combination in US 

13 May 2008: Start of Phase II Clinical Study for Rabies Monoclonal Antibody Combination in the Philippines

31 Mar. 2008: Crucell Announces Start of Phase II Clinical Study Rabies Monoclonal Antibody Combination in US

03 Jan. 2008: Crucell Enters Agreement with Sanofi Pasteur for Next-generation Biologicals against Rabies

3 Oct. 2007: Crucell presents Phase I results rabies antibody cocktail showing safety and ability to protect

14 July 2005: Crucell Announces Clinical Development of Human Monoclonal Antibody Combination Against Rabies

16 Nov. 2004: Crucell Discovers and Validates Human Monoclonal Antibody Product that Protects Against Rabies in Collaboration with CDC and TJU

Publications related to Crucell’s rabies antibody program are listed below. Please click on any of these to access the abstracts of the articles. For more Crucell scientific papers please use search word ‘Crucell’ at PubMed, http://www.ncbi.nlm.nih.gov./entrez/query.fcgi.

Goudsmit, J. et al. Comparison of an anti-rabies human monoclonal antibody combination with human polyclonal anti-rabies immune globulin. J Infect Dis. 2006. 193(6), 796-801.

Bakker, A.B. et al. Novel Human Monoclonal Antibody Combination Effectively Neutralizing Natural Rabies Virus Variants and Individual In Vitro Escape Mutants.  J Virol. 2005. 79(14), 9062-9068.

Kramer, R.A. et al. The human antibody repertoire specific for rabies virus glycoprotein as selected from immune libraries. Eur J Immunol. 2005. 35(7), 2131-2145.

Marissen, W.E., et al. Novel rabies virus-neutralizing epitope recognized by human monoclonal antibody: fine mapping and escape mutant analysis. J Virol. 2005. 79(8), 4672-4678.

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