Management Report – Information on the Company
We are a public limited liability company incorporated in Leiden, the Netherlands with the legal and commercial name Crucell N.V., registered under number 28087740. We were incorporated on October 9, 2000, as the holding company for Crucell Holland B.V., formerly called IntroGene B.V., following the combination of IntroGene B.V. and U-BiSys B.V. Our principal executive office is located at Archimedesweg 4-6, 2333 CN Leiden, the Netherlands. Our telephone number is +31 (0)71 519 9100. Our agent in the U.S. is CT Corporation, 111 Eighth Avenue, New York, New York 10011.
Business drivers
Our business strategy is based on the following business drivers:
Products
Leveraging presence of our marketed vaccines in public and private markets. We produce and sell established paediatric, respiratory and travel vaccines. We intend to enhance our position in these markets by highlighting the unique features of these products and by providing outstanding customer service in terms of delivery, reliability and quality and by leveraging our worldwide presence in both public and private markets.
Our core portfolio consists of the following products: Quinvaxem, the fully-liquid vaccine for protection against five important childhood diseases; Hepavax-Gene, the recombinant vaccine against hepatitis B; Epaxal, the only aluminium-free hepatitis A vaccine; Vivotif, the only oral anti-typhoid vaccine; Dukoral, the only internationally licensed oral vaccine with documented efficacy against diarrhea caused by cholera; and Inflexal V, the virosomal adjuvanted influenza vaccine for all age groups. We have manufacturing facilities in the Netherlands, Switzerland, Korea, Spain and Sweden.
Research and Development (R&D) product pipeline with competitive advantage
We believe that each of our selected products either targets unmet medical needs, improves current medications, or is perceived as a marketable product due to predictive study models and/or perceived favourable regulatory conditions. These products are predominantly based on our PER.C6 technology.
In addition, we have various discovery programs to find new vaccine and antibody leads.
Besides our portfolio of well known vaccines, we have a pipeline of new potential vaccines and antibodies. Product pipeline programs include vaccines against yellow fever, influenza, ebola, HIV, malaria, tuberculosis, human monoclonal antibodies against rabies, H5N1 antibodies, pandemic influenza virus. Our R&D activities are concentrated in our headquarters in the Netherlands. Product development is concentrated in our Swiss operations in Bern. Our R&D facilities are located in the Netherlands, Switzerland, Korea and Sweden.
Technologies – ongoing technology licensing program
We have a broad base of excellent technologies with applicability to vaccines, antibodies, other recombinant proteins and gene therapy. Our licensing program provides a source of revenue as well as the potential for future, additional revenue in the form of royalties from products developed by our licensees. In areas where we are not developing our own products, we offer our technologies to the biopharmaceutical industry for the development and production of diverse biopharmaceutical products.
We have developed various proprietary technologies such as PER.C6, AdVac, MAbstract, STAR, our virosomal technology, rCTB as well as our Hansenula polymorpha expression system. We believe our proprietary PER.C6 technology is well suited for the development and large-scale manufacturing of a wide range of biopharmaceuticals including vaccines, monoclonal antibodies, therapeutic proteins and gene therapy products. AdVac is used to develop novel adenoviral-based products. MAbstract can be used to develop human antibodies. Our STAR technology is useful for increasing production output of recombinant antibodies and therapeutic proteins on mammalian cell lines and we have indications that the technology is complementary to our PER.C6 technology.
You can download the following sections from our 2007 Annual Report and Form 20–F in PDF format below.
- Management Report (Complete Section) – (PDF – 794kb)
- Report of the Management Board – (PDF – 65kb)
- Information on the Company – (PDF – 307kb)
- Risk Factors – (PDF – 148kb)
- Operating and Financial Review and Prospects - (PDF - 185kb)
- Corporate Social Responsibility – (PDF – 58kb)
- Corporate Governance – (PDF – 180kb)
- Articles of Association and Share Capital - (PDF - 92kb)
- Report of Independent Registered Public Accounting Firm - (PDF - 49kb)
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